Fecal calprotectin concentrations in young children with cystic fibrosis: Authors response

Author's response to reviews Title:Is Fecal Calprotectin an Accurate Marker of Inflammation in Cystic Fibrosis? Authors:

Calprotectin in Cystic Fibrosis

BACKGROUND There is increasing evidence that intestinal inflammation plays a major role in gastrointestinal symptoms in cystic fibrosis (CF). Fecal calprotectin is a marker that is elevated in several gastrointestinal inflammatory diseases, but little is known about its value in CF. We aimed to look for associations of elevated fecal calprotectin among CF patients and whether its level correlat...

Pulmonary oxidative stress response in young children with cystic fibrosis.

BACKGROUND It has been suggested that oxidative stress contributes to lung injury in cystic fibrosis. There is, however, no direct evidence of increased pulmonary oxidative stress in cystic fibrosis nor of the effects of inflammation on the major pulmonary antioxidant, glutathione. A study was undertaken to measure these parameters in infants and young children in the presence or absence of pul...

Fecal Calprotectin Concentrations in Healthy Children Aged 1-18 Months

OBJECTIVE Fecal calprotectin (FC) is an established biomarker of gut inflammation. The aim of this study was to evaluate FC concentrations in healthy children between 1 and 18 months of age. METHODS Healthy children aged 1-18 months were enrolled in this study at the Department of Children's Health Care in Shanghai, China. Children's stool samples were collected and analyzed, and FC concentra...

The effect of probiotics on fecal calprotectin in patients with cystic fibrosis.

Cystic fibrosis (CF) is a common autosomal recessive disorder with different clinical manifestations, mainly in the gastrointestinal and respiratory tracts. This study was performed to access the effect of probiotics in the status of intestinal inflammation in a group of children with CF by measuring the calprotectin level in the fecal samples. Forty-seven patients with CF were enrolled in this...